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Related Experiment Videos

Citrullination is an inflammation-dependent process.

D Makrygiannakis1, E af Klint, I E Lundberg

  • 1Department of Medicine, Rheumatology Unit, CMM, L8-04, Karolinska University Hospital, Solna, S-17176 Stockholm, Sweden.

Annals of the Rheumatic Diseases
|March 17, 2006
PubMed
Summary
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Citrullinated proteins are found in various inflammatory tissues, indicating that citrullination is linked to inflammation, not specific diseases. This process was observed in rheumatoid arthritis, polymyositis, and inflammatory bowel disease.

Area of Science:

  • Immunology
  • Pathology

Background:

  • Citrullinated proteins are implicated in autoimmune diseases.
  • The role of citrullination in various inflammatory conditions requires further investigation.

Purpose of the Study:

  • To investigate the presence and distribution of citrullinated proteins in different inflammatory conditions.
  • To compare citrullination levels in affected and non-affected tissues.

Main Methods:

  • Immunohistochemistry was used to analyze synovial biopsy specimens from rheumatoid arthritis patients and healthy controls.
  • Muscle, intestinal, and tonsil tissues from patients with polymyositis, inflammatory bowel disease, and chronic tonsillitis were also examined.

Main Results:

  • Citrullinated proteins were detected in all rheumatoid arthritis synovial tissues and polymyositis-affected muscles.

Related Experiment Videos

  • Citrullination was present in inflamed tonsils and in inflammatory bowel disease tissues, with no significant difference between affected and unaffected areas.
  • Scarce citrullination was found in a minority of healthy synovial tissues.

    • Conclusions:

    • Citrullination is a common finding in a broad spectrum of inflammatory tissues.
    • The presence of citrullination appears to be dependent on the inflammatory process itself, rather than specific diseases.