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Updated: Aug 3, 2026

Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
Oncogene-induced senescence: putting the brakes on tumor development
Melanie Braig1, Clemens A Schmitt
1Department of Hematology/Oncology, Charité-Universitätsmedizin Berlin, Germany.
Abstract:
Cellular senescence, a permanent cell cycle arrest, is considered a safeguard mechanism that may prevent aged or abnormal cells from further expansion. Although the term "replicative senescence" stands for the widely accepted model of a terminal growth arrest due to telomere attrition, the significance of "oncogene-inducible senescence" remained an issue of debate over the years. A number of recent studies now show the effect of this acute and telomere-independent form of senescence as a tumor-protective, fail-safe mechanism in vivo that shares conceptual and possibly therapeutic similarities with the genetically encoded apoptosis machinery.
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