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Adjustable set point: to honor Harold T. Hammel.

Michel Cabanac¹

¹Departement de physiologie, Faculté de medecine, Université Laval, Quebec, G1K 7P4 Canada. michel.cabanac@phs.ulaval.ca

Journal of Applied Physiology (Bethesda, Md. : 1985)

|March 17, 2006

Summary

The thermoregulatory set point is crucial for maintaining body temperature. Recent challenges questioning its validity and the concepts of fever and anapyrexia are premature, based on current data.

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Area of Science:

Physiology
Homeostasis
Thermoregulation

Background:

Biological systems maintain stable internal conditions through regulation.
The set point theory explains how deviations trigger corrective responses.
Thermoregulation involves comparing actual temperature to a desired set point.

Purpose of the Study:

To evaluate recent challenges to the thermoregulatory set point concept.
To assess the validity of fever and anapyrexia as physiological responses.
To review arguments and data concerning thermoregulation set points.

Main Methods:

Literature review of existing arguments and data.
Analysis of challenges to the set point theory in thermoregulation.
Examination of evidence supporting or refuting fever and anapyrexia.

Main Results:

The concept of a thermoregulatory set point remains a fundamental principle.
Recent challenges have not provided sufficient evidence to discard the set point theory.
Fever and anapyrexia are considered meaningful concepts in thermoregulation.

Conclusions:

Abandoning the concepts of set point, fever, and anapyrexia is premature.
The set point theory provides a valuable framework for understanding thermoregulation.
Further research is needed to fully understand the nuances of thermoregulatory control.

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