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Endothelial function and exercise training: evidence from studies using animal models.

Jeffrey L Jasperse1, M Harold Laughlin

  • 1Department of Sports Medicine, Pepperdine University, Malibu, CA, USA. jeffrey.jasperse@pepperdine.edu

Medicine and Science in Sports and Exercise
|March 17, 2006
PubMed
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Endurance exercise training impacts endothelium-dependent dilation, with effects varying by training duration, artery size, and location. Exercise training generally improves dilation more in diseased states than in healthy individuals.

Area of Science:

  • Cardiovascular Physiology
  • Exercise Science

Background:

  • Endothelium-dependent dilation is crucial for arterial health.
  • Exercise training is known to influence vascular function.

Purpose of the Study:

  • To review animal model evidence on endurance exercise training's effects on endothelium-dependent dilation.
  • To identify factors modulating this response.

Main Methods:

  • Systematic review of experimental studies using animal models.
  • Analysis of data concerning training duration, artery characteristics, and health status.

Main Results:

  • Short-term training may enhance dilation in healthy animals, but effects diminish with longer durations.
  • Exercise training generally yields greater dilation improvements in disease states compared to healthy states.

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  • The overall impact on arterial endothelium is inconsistent across different vascular beds and animal models.

    • Conclusions:

    • The effect of endurance exercise on endothelium-dependent dilation is complex and multifactorial.
    • Training duration, artery size, anatomical location, and individual health status are key interacting factors.
    • Further research is needed to fully elucidate these interactions and their impact on vascular health.