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Updated: Aug 10, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

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Published on: November 8, 2016

Abatacept

Edward M Vital1, Paul Emery

  • 1Academic Unit of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, UK.

Drugs of Today (Barcelona, Spain : 1998)
|March 17, 2006
PubMed

New therapies, in particular the tumor necrosis factor-alpha-blocking drugs, have led to improved control of inflammation in rheumatoid arthritis for a proportion of patients. There remains a need for therapies for patients who do not respond to these drugs or in whom they are contraindicated or not tolerated. There is evidence that T cells are involved in the initiation and perpetuation of rheumatoid arthritis. Abatacept is the first in a new class of drugs targeted at T-cell function in autoimmune disease: the costimulation blockers. It has shown safety and efficacy in rheumatoid arthritis. Further trials of this and other costimulation blockers are in progress in rheumatoid arthritis and other diseases.

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