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[Correlation between immunochemical level and patient with caries].

Hao-Hong Huang1, Hao Yu, Lin Zhang

  • 1Dept. of Dentistry, The Second Affiliated Hospital of Qiqiha'er Medical College, Qiqiha'er 161006, China.

Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal of Stomatology
|March 18, 2006
PubMed
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Salivary secretory immunoglobulin A (SIgA), lysozyme (LZ), alkaline phosphatase (ALP), and lactic dehydrogenase (LDH) levels differ significantly between children with and without caries. These salivary immunochemical markers may be associated with caries incidence.

Area of Science:

  • Oral health research
  • Immunochemistry
  • Pediatric dentistry

Background:

  • Dental caries is a prevalent oral disease in children.
  • Salivary components play a role in oral health and disease prevention.
  • Understanding salivary markers associated with caries can aid in early detection and management.

Purpose of the Study:

  • To investigate the association between specific salivary immunochemical markers and the presence of dental caries in young children.
  • To compare levels of salivary secretory immunoglobulin A (SIgA), lysozyme (LZ), alkaline phosphatase (ALP), and lactic dehydrogenase (LDH) in children with and without caries.

Main Methods:

  • A case-control study involving 90 children aged 4-6 years, divided into caries and no-caries groups (45 participants each).
  • Salivary SIgA levels were measured using radio-immunoassay and single agar diffusion assay.

Related Experiment Videos

  • Levels of LZ, ALP, and LDH were determined using colorimetry and turbidimetry.

    • Main Results:

    • Significant differences in salivary levels of SIgA, LZ, ALP, and LDH were observed between children with and without caries (P < 0.05).
    • Lactic dehydrogenase (LDH) showed a non-significant difference between the groups (P > 0.05).

    Conclusions:

    • Salivary immunochemical profiles, including SIgA, LZ, and ALP, are associated with dental caries in children aged 4-6 years.
    • Age is a factor in caries incidence, and salivary markers may offer insights into caries susceptibility.