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Receptor-mediated changes in intracellular [Ca2+] in cultured rat brain capillary endothelial cells
P A Revest1, N J Abbott, J I Gillespie
1Biomedical Sciences Division, King's College London, U.K.
Brain Research
|May 17, 1991
Abstract:
Agents which are known to alter blood-brain barrier permeability have been tested for their ability to raise [Ca2+]i in rat brain capillary endothelial cells loaded with the calcium indicator Fura-2, and subjected to dual wavelength excitation. The cells show increases in [Ca2+]i in response to bradykinin, histamine and ATP. Possible sources of this calcium are discussed.