Related Experiment Video

Updated: Aug 8, 2026

An Ex vivo Culture System to Study Thyroid Development
08:33

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

Cyclin D1 protein expression in human thyroid gland and thyroid cancer

L Temmim1, A K Ebraheem, H Baker

  • 1Kuwait Cancer Control Center.

Anatomia, Histologia, Embryologia
|March 18, 2006
PubMed

Insights

Cyclin D1 protein was found in specific cell areas within thyroid carcinomas of young Kuwaiti patients. This focal expression may indicate a progression towards more aggressive cancer, potentially leading to metastases.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Cell cycle progression is regulated by cyclin-dependent kinases (CDKs) and cyclins.
  • Cyclin D1 is a key cyclin implicated in cell cycle control.
  • Altered cyclin gene expression is increasingly linked to human cancers.

Purpose of the Study:

  • To investigate the expression and role of Cyclin D1 protein in thyroid carcinomas.
  • To determine if Cyclin D1 is associated with malignant progression in thyroid cancer.

Main Methods:

  • Immunohistochemistry was used to detect Cyclin D1 protein expression.
  • Thyroid carcinoma tissues from young Kuwaiti patients were analyzed.
  • Expression patterns were correlated with clinical and histopathological parameters.

Main Results:

  • Focal nuclear Cyclin D1 immunostaining was observed in 46% of thyroid carcinoma cases.
  • The majority of carcinoma cells showed negative or cytoplasmic staining for Cyclin D1.
  • No statistically significant correlation was found between focal Cyclin D1 staining and tested parameters.

Conclusions:

  • Focal Cyclin D1 expression in thyroid carcinomas may signify areas of malignant transformation.
  • These positive foci could be indicative of a pathway towards increased aggressiveness and metastasis.
  • Further research is needed to fully elucidate the role of Cyclin D1 in thyroid cancer progression.

More Related Videos

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice07:02

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

Related Concept Videos

Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...