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Six cases of suppurative lymphadenitis caused by Burkholderia pseudomallei infection

Maciej Piotr Chlebicki1, Ban Hock Tan

  • 1Department of Internal Medicine, Infectious Diseases Unit, Singapore General Hospital, Outram Road, Singapore 169608, Singapore. pchlebicki@hotmail.com

Transactions of the Royal Society of Tropical Medicine and Hygiene
|March 18, 2006
PubMed

Insights

Melioidosis, a Burkholderia pseudomallei infection, rarely causes suppurative lymphadenitis. This study highlights unusual presentations like inguinal and mediastinal lymph node involvement in Singapore.

Area of Science:

  • Infectious Diseases
  • Microbiology

Background:

  • Melioidosis, caused by Burkholderia pseudomallei, is prevalent in Southeast Asia and Australia.
  • It presents with diverse clinical manifestations, from acute sepsis to chronic localized infections.
  • Suppurative lymphadenitis is an uncommon presentation of melioidosis.

Observation:

  • Six adult cases of melioidosis-induced suppurative lymphadenitis were observed in Singapore (1997-2000).
  • A notable difference from prior reports was the lymph node distribution.
  • Four patients had unilateral inguinal lymphadenitis; two had mediastinal lymphadenitis with prolonged fever.

Findings:

  • This study identified unusual patterns of lymph node involvement in melioidosis.
  • Inguinal and mediastinal lymphadenitis were observed, differing from the typical head and neck involvement.
  • All patients responded well to antimicrobial therapy.

Implications:

  • Melioidosis should be considered in the differential diagnosis of regional suppurative lymphadenitis.
  • Clinicians in endemic areas should be aware of diverse presentations, including unusual lymph node involvement.
  • Prompt diagnosis and treatment are crucial for favorable outcomes in melioidosis patients.

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