[Adrenergic effects on the renal function and their mechanisms]

The experiments on rats have shown that the activation of alpha-adrenoceptors decreases the glomerular filtration as well as sodium and water reabsorption against a background of a decrease in the blood content of vasopressin, renin, angiotensin II, aldosterone and a fall of the renal cortex level of thromboxane B2. alpha-, alpha 1- and beta-adrenoceptors blockade decreases diuresis as well as sodium and potassium excretion due to an increase in the level of vasopressin, renin and insulin. The stimulation of beta-adrenoceptors accelerates the glomerular filtration, decreases sodium reabsorption and potassium excretion against a background of an increase in the secretion of vasopressin, renin, insulin and a fall of the blood level of angiotensin II and aldosterone and an elevation of the prostaglandin E2 content in the renal cortex. A conclusion is drawn that the adrenergic regulation of the kidneys is mediated to a considerable degree by hormones which regulate the water-salt metabolism and vascular tonus in vivo.