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Updated: Aug 10, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Principles of appropriate antibiotic use

Michael S Niederman1

  • 1Department of Medicine, Winthrop University Hospital, Mineola, NY 11501, USA. MNiederman@Winthrop.gov

International Journal of Antimicrobial Agents
|March 18, 2006
PubMed

Insights

Incorrect antibiotic use for respiratory infections is common. Promoting rational prescribing and short-duration therapies can improve compliance and combat antibiotic resistance.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Public Health

Background:

  • Macrolides and quinolones are frequently misused for respiratory tract infections.
  • Broad-spectrum antibiotic use rose significantly in the 1990s, often inappropriately.
  • Existing guidelines advocate for rational antibiotic therapy and prudent prescribing.

Purpose of the Study:

  • To highlight the issue of inappropriate antibiotic use in respiratory infections.
  • To explore the relationship between antibiotic use, compliance, and resistance.
  • To propose strategies for improving antibiotic therapy efficacy and adherence.

Main Methods:

  • Literature review on antibiotic prescribing patterns and resistance.
  • Analysis of factors influencing compliance and regimen complexity.
  • Discussion of evidence-based guidelines for respiratory tract infections.

Main Results:

  • Inappropriate antibiotic prescribing for respiratory infections remains a significant concern.
  • Strong correlations exist between appropriate antibiotic use, patient compliance, and antimicrobial resistance.
  • Regimen complexity negatively impacts patient compliance.

Conclusions:

  • Short-duration, high-compliance antibiotic regimens with proven clinical efficacy are needed.
  • Programs promoting rational antibiotic use are crucial.
  • Targeting inappropriate prescribing for viral infections and overuse of broad-spectrum agents is essential.

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