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Updated: Aug 10, 2026

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
Published on: May 30, 2011
Pediatric perfusion MR imaging using arterial spin labeling
Jiongjiong Wang1, Daniel J Licht
1Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA. wangj3@mail.med.upenn.edu
Insights
Arterial spin label (ASL) perfusion MRI offers a noninvasive way to measure cerebral blood flow (CBF) in children. This technique aids in evaluating pediatric brain injury and recovery, improving management strategies.
Area of Science:
- Neurology
- Medical Imaging
- Pediatrics
Background:
- Cerebral blood flow (CBF) is crucial for assessing pediatric brain injury and recovery.
- Traditional CBF measurement methods pose challenges in pediatric patients.
Purpose of the Study:
- To present the technical aspects of ASL perfusion MRI in pediatrics.
- To discuss the clinical applications and potential impact of ASL MRI on pediatric brain injury management.
Main Methods:
- Utilizing arterial spin label (ASL) perfusion Magnetic Resonance Imaging (MRI).
- Noninvasive measurement of cerebral blood flow (CBF).
Main Results:
- ASL perfusion MRI enables noninvasive CBF measurement across all age groups.
- Facilitates evaluation of pediatric brain injury and recovery.
Conclusions:
- ASL perfusion MRI is a valuable, noninvasive tool for pediatric neuroimaging.
- This technique has the potential to influence management strategies for pediatric brain conditions.
Abstract:
Cerebral blood flow (CBF, cerebral perfusion) mirrors cerebral metabolic demand and neuronal function, and therefore, is a vital parameter in the evaluation of pediatric brain injury and recovery. Until recently, measurement of CBF involved intravenous bolus injection of contrast agents or nuclear medicine methods that were technically difficult or ethically problematic in pediatrics. The development of arterial spin label (ASL) perfusion MR imaging as a noninvasive method for measuring CBF allows for the increased ability to measure this vital physiologic parameter in any age group. This article presents the technical aspects of performing ASL perfusion MR imaging in pediatrics, and discusses its current use in clinical studies and its potential for influencing important management strategies in specific disease entities.
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