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Neurological abnormalities in young adults born preterm.

M Allin1, M Rooney, T Griffiths

  • 1Section of General Psychiatry, Division of Psychological Medicine, Box 063, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK. matthew.allin@iop.kcl.ac.uk

Journal of Neurology, Neurosurgery, and Psychiatry
|March 18, 2006
PubMed
Summary

Neurological abnormalities persist into adulthood for individuals born very preterm (VPT). These VPT adults show increased neurological signs associated with reduced IQ, highlighting long-term neurodevelopmental impacts.

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Area of Science:

  • Neuroscience
  • Developmental Pediatrics
  • Neurology

Background:

  • Individuals born very preterm (VPT) face higher risks of neurological issues and cognitive deficits.
  • It remains unclear if these early neurological signs persist or resolve by adulthood.

Purpose of the Study:

  • To investigate the persistence of neurological signs in very preterm individuals into adulthood.
  • To determine the association between adult neurological signs and cognitive function in VPT individuals.

Main Methods:

  • A comprehensive neurological examination was performed on 153 VPT individuals and 71 term-born controls at 17-18 years of age.
  • Neurological signs were categorized into primary and integrative domains (sensory integration, motor confusion, sequencing).
  • Longitudinal data from birth, 4, 8, and 18 years of age were utilized.

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Main Results:

  • VPT young adults exhibited significantly higher total, primary, and integrative neurology scores compared to controls.
  • Increased scores in sensory integration and motor confusion were observed in the VPT group.
  • Integrative neurological abnormalities strongly correlated with reduced IQ, while primary abnormalities did not.

Conclusions:

  • Neurological abnormalities are more prevalent in very preterm adults compared to term-born individuals.
  • These persistent neurological signs in VPT adults are significantly linked to impaired neuropsychological function, particularly reduced IQ.