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Colonic perforation at CT colonography: assessment of risk in a multicenter large cohort
Jacob Sosna1, Arye Blachar, Michal Amitai
1Department of Radiology, Hadassah Hebrew University Medical Center, POB 12000, Jerusalem, Israel. jacobs@hadassah.org.il
Insights
Colonic perforation during computed tomographic (CT) colonography is a rare event, occurring in 0.059% of studies. Patients experiencing perforation were typically older and had underlying colonic conditions.
Area of Science:
- Radiology
- Gastroenterology
- Surgical Oncology
Background:
- Computed tomographic (CT) colonography is an alternative to conventional colonoscopy.
- Assessing the safety of CT colonography is crucial for its clinical adoption.
Purpose of the Study:
- To determine the incidence of colonic perforation during CT colonography.
- To describe the clinical features and management of colonic perforations.
Main Methods:
- Retrospective review of 11,870 CT colonography studies across 11 centers.
- Data collected included patient demographics, risk factors, perforation location, mechanism, and treatment.
Main Results:
- Seven cases of colonic perforation occurred, yielding an incidence of 0.059%.
- Perforations were more common in older, symptomatic patients with underlying colonic disease.
- Four patients (57%) required surgical intervention.
Conclusions:
- Colonic perforation is a rare complication of CT colonography.
- Older age and pre-existing colonic conditions are risk factors for perforation.
Purpose:
To assess retrospectively the incidence, clinical features, and treatment of colonic perforation at computed tomographic (CT) colonography in a large multicenter cohort.
Materials And Methods:
The study was performed in accordance with the institutional ethics committees' requirements of a retrospective review in each of the participating centers, and no informed consent was required. A review of all patients who underwent CT colonography between January 2001 and December 2004 in 11 medical centers representing more than 95% of studies performed in a single country was performed to determine the rate of colorectal perforation. Data about patient demographics and patient- and procedure-related risk were recorded. Information about the location of the perforation, its likely mechanism, and treatment was collected. Analysis included calculation of rates of colonic perforation and surgical treatment and of 95% confidence intervals.
Results:
A total of 11 870 CT colonographic studies were performed in 6837 (57.6%) men and 5033 (42.4%) women (mean age, 59.9 years; range, 38-90 years) with seven cases of colorectal perforation, yielding a risk rate of 0.059% (one of 1696 studies; 95% confidence interval: one of 974, 971 of 6537). The mean age of the patients with perforation was 77.8 years. Six (84%) of seven cases of perforation occurred in symptomatic patients at high risk for colorectal neoplasia, and one (16%) occurred in an asymptomatic average-risk patient. All studies were performed after insufflation of room air. Six (84%) cases of perforation occurred in patients in whom a rectal tube was inserted, and in five of them, a balloon was inflated. Five (71%) cases of perforation occurred in the sigmoid colon; and two (29%), in the rectum. Four (57%) patients (one in 2968 patients; 95% confidence interval: 1.5 in 10 000, 14.7 in 10 000) required surgical treatment. Possible factors that contributed to perforation were left inguinal hernia containing colon (n = 4), severe diverticulosis (n = 3), and obstructive carcinoma (n = 1).
Conclusion:
Perforation of the colon and rectum is a rare complication of CT colonography. Older age and underlying concomitant colonic disease were present in patients with perforation.
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