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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Microvascular disease and endothelial dysfunction in chronic kidney diseases: therapeutic implication

Narisa Futrakul1, Punnee Butthep, Suthiluk Patumraj

  • 1King Chulalongkorn Memorial Hospital and Ramathibody Hospital, Bangkok, Thailand. fmednft@md.chula.ac.th

Clinical Hemorheology and Microcirculation
|March 18, 2006
PubMed

Insights

Biomarkers for endothelial injury in chronic kidney disease (CKD) were studied. Increased circulating endothelial cells and depleted vascular endothelial growth factor (VEGF) indicate injury, which can be treated with vasodilators.

Area of Science:

  • Nephrology
  • Cardiovascular Biology
  • Endothelial Biology

Background:

  • Endothelial injury is implicated in chronic kidney disease (CKD) pathogenesis.
  • Identifying reliable biomarkers for endothelial dysfunction in CKD is crucial for effective treatment.

Purpose of the Study:

  • To investigate biomarkers of endothelial injury in patients with chronic kidney disease.
  • To explore the relationship between endothelial cell markers, growth factors, and intrarenal hemodynamics in CKD.

Main Methods:

  • Assessment of circulating endothelial cells (CECs) and soluble VCAM-1 (sVCAM).
  • Measurement of transforming growth factor beta (TGFB) and vascular endothelial growth factor (VEGF).
  • Evaluation of intrarenal hemodynamics in 50 CKD patients.

Main Results:

  • Significantly increased CECs and depleted VEGF/TGFB ratio observed in CKD patients.
  • No significant difference in sVCAM compared to controls.
  • Intrarenal hemodynamics showed characteristic maladjustment, with reduced peritubular capillary flow.

Conclusions:

  • Elevated CECs are sensitive biomarkers for endothelial cell injury in CKD.
  • VEGF depletion supports endothelial injury, correlating with glomerular and peritubular capillary dysfunction.
  • Correcting hemodynamic maladjustment with vasodilators may restore renal function in CKD.

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