Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Triglyceride in plasma: prospective effects on microcirculatory functions.

Nobuji Maeda1, Iwona Cicha, Norihiko Tateishi

  • 1Department of Integrated Basic Medical Science, School of Medicine, Ehime University, Japan. nmaeda@m.ehime-u.ac.jp

Clinical Hemorheology and Microcirculation
|March 18, 2006
PubMed
Summary

High plasma triglyceride levels increase red blood cell (RBC) aggregation, impacting microcirculation flow and oxygen delivery. This study links elevated triglycerides to impaired tissue oxygenation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nanomedicines for modulating the gut-brain axis.

Nanomedicine (London, England)·2026
Same author

Gold-modified superparamagnetic iron oxide nanoparticles: Magnetic accumulation under flow conditions and toxicity evaluation in vitro and in vivo.

Nanotoxicology·2026
Same author

Polycatecholamine nanocoatings on stainless steel: the effect on attachment of human fibroblasts and platelets.

Beilstein journal of nanotechnology·2026
Same author

New insights into the mechanisms of cellular interactions and toxicity of nanomaterials.

Nanomedicine (London, England)·2025
Same author

Correction: Single immersion in cold water below 4 °C: A health hazard in young healthy men?

PloS one·2025
Same author

Multiscale physics-based <i>in silico</i> modelling of nanocarrier-assisted intravascular drug delivery.

Frontiers in drug delivery·2025

Area of Science:

  • Biomedical Engineering
  • Hematology
  • Physiology

Background:

  • Elevated plasma triglyceride levels are associated with cardiovascular risks.
  • Red blood cell (RBC) aggregation is a key factor in blood rheology and microcirculation.
  • Understanding the impact of plasma lipids on RBC behavior is crucial for assessing microvascular function.

Purpose of the Study:

  • To investigate the effect of plasma triglyceride concentration on red blood cell aggregation.
  • To explore the implications of altered RBC aggregation on microcirculatory blood flow and oxygen release.

Main Methods:

  • Blood samples were collected from a single subject after high-fat and low-fat meals to minimize inter-individual variability.
  • Plasma triglyceride levels were quantified using an enzymatic method.

Related Experiment Videos

  • Red blood cell rouleaux formation rate was measured using a low shear rheoscope.

    • Main Results:

    • A positive correlation was observed between plasma triglyceride concentration and the rate of red blood cell rouleaux formation.
    • Increased RBC aggregation was linked to altered flow dynamics in microcirculation, potentially reducing flow resistance in arterioles but causing inhomogeneity in capillaries.
    • Enhanced RBC aggregation was found to impede oxygen release from red blood cells in microvessels.

    Conclusions:

    • Elevated plasma triglyceride levels significantly enhance red blood cell aggregation.
    • This enhanced aggregation alters RBC flow behavior in microcirculation, potentially increasing flow resistance and impairing homogeneous tissue oxygenation.
    • The findings suggest a mechanism by which hypertriglyceridemia contributes to microcirculatory dysfunction and reduced oxygen delivery.