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Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
Imaging Studies II: Ultrasonography01:24

Imaging Studies II: Ultrasonography

IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
Imaging Studies V: Intravenous Urography and Retrograde Pyelography01:22

Imaging Studies V: Intravenous Urography and Retrograde Pyelography

IntroductionIntravenous Urography (IVU) and Retrograde Pyelography (RP) are important diagnostic imaging techniques used to evaluate the urinary system. These methods help identify structural abnormalities, obstructions, and functional issues in the kidneys, ureters, and bladder. Both procedures use iodine-based contrast media to enhance the visibility of urinary tract structures on X-ray images, though they differ in their methods and indications.1. Intravenous Urography (IVU)Intravenous...
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...

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Related Experiment Video

Updated: Jun 18, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Imaging glomeruli in renal biopsy specimens.

Carrie L Phillips1, Vincent H Gattone, Stephen M Bonsib

  • 1Division of Nephrology, Department of Medicine, Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, IN, USA. cphilli3@iupui.edu

Nephron. Physiology
|March 18, 2006
PubMed
Summary
This summary is machine-generated.

New microscopy and software allow detailed 3D analysis of the complex glomerular filtration barrier. These advanced techniques improve visualization and segmentation of glomerular components for better understanding of kidney structure and disease.

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Last Updated: Jun 18, 2026

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Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
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Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

Area of Science:

  • Nephrology
  • Cell Biology
  • Microscopy

Background:

  • Glomerular capillary loops are intricate vascular filters essential for kidney function.
  • Their complex 3D structure poses challenges for traditional 2D analysis, especially in disease states.
  • Understanding glomerular morphology is key to diagnosing and treating kidney diseases.

Purpose of the Study:

  • To review advanced imaging and analysis techniques for studying glomerular structure.
  • To highlight the benefits of new methodologies for visualizing complex glomerular components.
  • To provide insights for researchers studying kidney filtration and pathology.

Main Methods:

  • Application of two-photon microscopy for enhanced 3D imaging.
  • Utilization of advanced computer software for multicolor imaging.
  • Implementation of single-cell segmentation techniques for detailed analysis.

Main Results:

  • New methodologies enable high-resolution, three-dimensional visualization of glomerular architecture.
  • Advanced imaging facilitates detailed segmentation of podocytes, endothelial cells, and the extracellular matrix.
  • These techniques overcome limitations of conventional 2D histochemistry for complex structures.

Conclusions:

  • Modern microscopy and computational tools offer unprecedented detail in analyzing glomerular structures.
  • These advancements are crucial for interpreting glomerular pathology and understanding filtration barrier dynamics.
  • Future research can leverage these techniques for deeper insights into kidney health and disease.