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Updated: Aug 10, 2026

Glutamine Flux Imaging Using Genetically Encoded Sensors
Published on: July 31, 2014
The glutamine story: where are we now?
1Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA. Paul.Wischmeyer@UCHSC.edu
Glutamine may be life-saving in critical illness, especially at doses over 0.3 g/kg/day. It acts as a stress signaling molecule, suggesting use as a drug, not just nutrition.
Area of Science:
- Critical care medicine
- Nutritional science
- Molecular biology
Background:
- Glutamine's role in critical illness has been debated.
- Recent data suggest potential life-saving benefits.
Purpose of the Study:
- To evaluate if glutamine is a life-saving nutrient in critical illness.
- To explore gene-nutrient interactions and glutamine's mechanisms of action.
Main Methods:
- Review of recent data and meta-analysis.
- Examination of molecular mechanisms of glutamine action.
- Assessment of gene-nutrient interactions.
Main Results:
- Meta-analysis indicates glutamine benefits mortality in critical illness.
- Mechanisms include tissue protection, reduced inflammation, improved metabolism, and reduced oxidant stress.
- Optimal administration settings and methods require further study.
Conclusions:
- Glutamine may be life-saving in critical illness, particularly at doses >0.3 g/kg/day.
- It functions as a stress signaling molecule, best used as a pharmacologic agent, not nutritional replacement.
- Multicenter trials are needed to investigate glutamine as a drug independent of nutritional needs.
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