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Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes

T T Chowdhury1, R N Appleby, D M Salter

  • 1Medical Engineering Division and IRC in Biomedical Materials, Department of Engineering, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK. t.t.chowdhury@qmul.ac.uk

Biomechanics and Modeling in Mechanobiology
|March 18, 2006
PubMed
Summary

Mechanical loading affects chondrocyte responses like nitric oxide (NO) release and proteoglycan synthesis. Integrins mediate these cellular responses to mechanical stress, even with interleukin-1 beta (IL-1 beta) present.

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