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Published on: March 23, 2018
Anti-CD38 autoantibodies in type? diabetes
Roberto Mallone1, Paolo Cavallo Perin
1INSERM U580, Institut Necker, U580-Batiment Sevres, 161 rue de Sèvres, 75015 Paris, France. mallone@necker.fr
Diabetes/Metabolism Research and Reviews
|March 18, 2006
Summary
Type 1 and type 2 diabetes share autoimmune markers, particularly anti-CD38 autoantibodies. These autoantibodies impact calcium mobilization and insulin secretion, affecting glucose homeostasis in both diabetes types.
Area of Science:
- Endocrinology and Immunology
- Metabolic Diseases Research
Background:
- Diabetes mellitus presents as type 1 (autoimmune) and type 2 (insulin resistance, beta cell dysfunction).
- Increasing evidence suggests overlap, with insulin resistance in type 1 and autoimmunity markers in type 2 diabetes.
Purpose of the Study:
- To investigate the role and prevalence of anti-CD38 autoantibodies in type 1 and type 2 diabetes.
- To explore the unique functional properties of anti-CD38 autoantibodies concerning beta cell function.
Main Methods:
- Detection and prevalence assessment of anti-CD38 autoantibodies in type 1 and type 2 diabetic patients.
- Analysis of anti-CD38 autoantibody effects on calcium mobilization and insulin secretion.
Main Results:
- Anti-CD38 autoantibodies are found in both type 1 and type 2 diabetes.
- Prevalence is higher in long-standing type 1 and type 2 diabetes compared to new-onset type 1.
- These autoantibodies exhibit unique stimulatory effects on Ca(2+) mobilization and insulin secretion.
Conclusions:
- Autoimmunity may contribute to beta cell dysfunction in both type 1 and type 2 diabetes.
- Anti-CD38 autoantibodies represent a significant factor in the pathogenesis and control of glucose homeostasis in diabetes.
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