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Updated: Aug 10, 2026

06:48
CD Spectroscopy to Study DNA-Protein Interactions
Published on: February 10, 2022
[Studies on Ru(bipy) 2dppx(2+) as interacting mode spectroscopic probe of DNA]
1College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
Guang Pu Xue Yu Guang Pu Fen Xi = Guang Pu
|March 21, 2006
Abstract:
The interacting mode of adriamycin with DNA has been studied by the use of molecular "light switch" complex Ru(bipy)2-dppx(2+) as a interacting mode spectroscopic probe. The results of the influence of ADM on the fluorescence and Scatchard equation of Ru(bipy)2 dppx(2+) -DNA system indicate that ADM intercalates the base pairs of DNA. Compared with normal DNA interacting mode spectroscopic probe EB, Ru(bipy)2dppx(2+) has the advantages of higher sensitivity, lower toxicity, higher stability and simplicity.

