Related Experiment Video

Updated: Aug 10, 2026

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice
14:10

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

Published on: July 29, 2022

[Salmonella enteritidis: an unusual meningitis agent in an adult patient]

Gökhan Metan1, Emine Alp, Duygu Eşel

  • 1Erciyes Universitesi Tip Fakültesi, infeksiyon Hastaliklan ve Klinik Mikrobiyoloji Anabilim Dali, Kayseri.

Mikrobiyoloji Bulteni
|March 21, 2006
PubMed

Insights

Salmonella meningitis is rare in adults but serious. This case highlights successful treatment of Salmonella enteritidis meningitis in an immunocompromised patient using ceftriaxone, offering hope for similar rare infections.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Microbiology

Background:

  • Salmonella species commonly cause enterocolitis and sepsis.
  • Salmonella meningitis is a rare but potentially fatal condition in adults, particularly those who are immunocompromised.

Observation:

  • A 71-year-old male with immune thrombocytopenic purpura, treated with azathioprine and prednisolone, developed Salmonella enteritidis meningitis.
  • Cerebrospinal fluid culture confirmed S. enteritidis, showing intermediate susceptibility to ampicillin but susceptibility to cefotaxime, trimethoprim-sulphamethoxazole, ciprofloxacin, and chloramphenicol.

Findings:

  • The patient was successfully treated with intravenous ceftriaxone.
  • Complete recovery was achieved, with the patient discharged cured.

Implications:

  • This case underscores the importance of considering Salmonella meningitis in immunocompromised adults presenting with neurological symptoms.
  • Prompt diagnosis and appropriate antibiotic therapy, such as ceftriaxone, are crucial for favorable outcomes in rare Salmonella meningitis cases.
  • Reviewing similar cases aids in understanding treatment strategies for this uncommon but severe infection.

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Reservoir of Infection01:30

Reservoir of Infection

Infectious diseases arise from intricate interactions between pathogens and their reservoirs. A reservoir of infection refers to the natural habitat where a pathogen lives, grows, and multiplies, serving as a continual source of infection. Reservoirs are broadly classified as either living or nonliving, and each plays a unique role in disease transmission, significantly influencing public health interventions and control strategies.Humans act as reservoirs for a wide array of pathogens,...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...