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Related Experiment Videos

Asymptomatic or minimally symptomatic hyperCKemia: histopathologic correlates.

Ron Dabby1, Menachem Sadeh, Oscar Herman

  • 1Department of Neurology, Wolfson Medical Center, Holon, Israel. dabbyr@netvision.net.il

The Israel Medical Association Journal : IMAJ
|March 21, 2006
PubMed
Summary

Persistent high creatine kinase (CK) levels in individuals without symptoms may indicate underlying muscle abnormalities. Over half of patients with elevated CK showed abnormal muscle biopsies, though specific diagnoses like muscular dystrophy were rare.

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Area of Science:

  • Neurology
  • Muscle Pathology
  • Biochemistry

Background:

  • Persistent elevation of creatine kinase (CK) levels can occur without apparent neuromuscular disorders.
  • The necessity of extensive investigations, including muscle biopsy, for individuals with asymptomatic hyperCKemia remains unclear.

Purpose of the Study:

  • To investigate the muscle pathology in patients presenting with asymptomatic or minimally symptomatic hyperCKemia.

Main Methods:

  • Review of clinical and laboratory data from patients with persistent hyperCKemia and normal neurological examinations.
  • Evaluation of muscle biopsy findings, including histopathology and immunohistochemistry.

Main Results:

  • Abnormal muscle biopsy findings were observed in 55% of the 40 patients studied.

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  • Specific muscular dystrophy diagnoses were identified in 8% of patients via abnormal dystrophin staining.
  • Electromyography (EMG) showed myopathic changes in 26% of tested patients, but did not correlate with biopsy findings.

    • Conclusions:

    • A significant proportion of individuals with asymptomatic or minimally symptomatic hyperCKemia exhibit abnormal muscle pathology.
    • While muscle biopsies can reveal abnormalities, specific diagnoses like muscular dystrophy are infrequent in this cohort.