Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Understanding rheumatoid arthritis].

Jean Sibilia1, Christelle Sordet, Dalila Mrabet

  • 1Service de rhumatologie, CHU Strasbourg, EA physiopathologie des arthrites, Université Louis Pasteur.

La Revue Du Praticien
|March 21, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"It was red, it was inflamed": A qualitative study of patient perspectives on musculoskeletal ultrasound in rheumatoid arthritis care.

Patient education and counseling·2026
Same author

[French medical studies: Educational reforms since 2018].

La Revue du praticien·2026
Same author

Borrelia Infections Under B Cell-Depleting Therapies: A Systematic Review of Diagnostic Challenges and Outcomes With Special Focus on Neurological Forms.

European journal of neurology·2026
Same author

Systemic lupus pregnancies are characterized by an intrinsic pro-inflammatory monocyte transcriptome, driven by an aberrant miRNA signature.

Journal of translational autoimmunity·2026
Same author

Screening for transthyretin amyloid cardiomyopathy in patients with musculoskeletal symptoms: Red flags in the rheumatology/orthopedics practice setting.

Joint bone spine·2025
Same author

International development and validation of a multilingual bank of items for the self-assessment of essential knowledge by systemic lupus erythematosus patients: the SLE Knowledge Assessment score (SLAKE).

Rheumatology (Oxford, England)·2025
Same journal

[Prolonged fever].

La Revue du praticien·2026
Same journal

[Lower gastrointestinal bleeding].

La Revue du praticien·2026
Same journal

[Management of antiplatelet agents and oral anticoagulants in cases of gastrointestinal bleeding].

La Revue du praticien·2026
Same journal

[A history of child abuse intervention in the West].

La Revue du praticien·2026
Same journal

[Agranulocytose médicamenteuse].

La Revue du praticien·2026
Same journal

[Patient education in heart failure].

La Revue du praticien·2026
See all related articles

Rheumatoid arthritis involves complex immune cell interactions and mediators, leading to chronic inflammation and joint destruction. Understanding these mechanisms offers new therapeutic targets for this severe inflammatory disease.

Area of Science:

  • Immunology
  • Rheumatology
  • Inflammation Biology

Background:

  • Rheumatoid arthritis (RA) is a severe inflammatory rheumatic disease.
  • Immune mechanisms in RA involve innate and adaptive immunity.
  • Key cellular actors include synoviocytes, macrophages, T cells, and B cells.

Purpose of the Study:

  • To elucidate the immune mechanisms underlying rheumatoid arthritis.
  • To clarify the chronology and cascade of events in rheumatoid synovitis.
  • To identify new therapeutic targets based on a deeper understanding of RA pathogenesis.

Main Methods:

  • Review and synthesis of current knowledge on RA immune pathways.
  • Analysis of cellular and molecular mediators involved in synovitis.
  • Examination of the interplay between innate and adaptive immune responses in RA.

Related Experiment Videos

Main Results:

  • RA pathogenesis involves early innate immunity activation, likely by bacterial agents.
  • Activated synoviocytes and macrophages release pro-inflammatory cytokines (e.g., TNFa, IL1, IL6, IL17).
  • Chronic inflammation and synovial proliferation lead to osteo-articular destruction via proteases and the RANK/RANK-ligand pathway.

Conclusions:

  • The intricate immune network in RA drives persistent inflammation and joint damage.
  • Dysregulation of immune mediators and insufficient physiological regulators contribute to RA chronicity.
  • Advances in understanding RA immuno-pathology are paving the way for novel therapeutic strategies.