Related Experiment Video
Updated: Aug 9, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
Published on: April 16, 2019
Emerging roles of DP and CRTH2 in allergic inflammation
1Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, D-53155 Bonn, Germany. Kostenis@uni-bonn.de
Abstract:
The lipid mediator prostaglandin D(2) (PGD(2)) has long been implicated in various inflammatory diseases including asthma. PGD(2) elicits biological responses by activating two seven-transmembrane (7TM) G-protein-coupled receptors, the D-prostanoid receptor DP and the chemoattractant receptor homologous-molecule expressed on T-helper-type-2 cells (CRTH2), which are linked to different signaling pathways. Understanding how immune cells integrate and coordinate signals that are triggered by the same ligand is crucial for the development of novel anti-inflammatory therapies. Here, we examine the roles of DP and CRTH2 in the orchestration of complex inflammatory processes, and discuss their importance as emerging targets for the treatment of asthma and inflammatory diseases.
Related Concept Videos
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Inflammatory Bowel Disease III: Crohn's Disease
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Acute Inflammation I: Inflammatory Response
Allergic Reactions
Asthma I: Introduction
