Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Isolation-induced vocalization in Wistar rat pups is not increased by naltrexone.

S E Carden1, M A Hofer

  • 1Department of Developmental Psychobiology, New York State Psychiatric Institute, NY.

Physiology & Behavior
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Family Nurture Intervention in preterm infants alters frontal cortical functional connectivity assessed by EEG coherence.

Acta paediatrica (Oslo, Norway : 1992)·2015
Same author

Unexplained infant crying: an evolutionary perspective.

Acta paediatrica (Oslo, Norway : 1992)·2002
Same author

Development of rats' maternally directed orienting behaviors from birth to day 2.

Developmental psychobiology·2002
Same author

Developmental effects of selective breeding for an infantile trait: the rat pup ultrasonic isolation call.

Developmental psychobiology·2001
Same author

Selective breeding for infant vocal response: a role for postnatal maternal effects?

Developmental psychobiology·2001
Same author

Maternally directed orienting behaviors of newborn rats.

Developmental psychobiology·1999
Same journal

Sex-dependent behavioral and prefrontal BDNF mRNA responses to extinction training and short-term citalopram after fear conditioning in rats.

Physiology & behavior·2026
Same journal

Social instability alters the topography of adolescent and adult social behavior and amygdala function.

Physiology & behavior·2026
Same journal

Mitochondrial remodeling in obesity: mechanistic links to impaired energy metabolism and therapeutic perspectives.

Physiology & behavior·2026
Same journal

Orexinergic and opioidergic receptors interaction in the dentate gyrus of the hippocampus on modulation of formalin-induced inflammatory pain responses in the rat.

Physiology & behavior·2026
Same journal

Combined environmental enrichment and aerobic exercise improve cognitive recovery in male rats after bilateral common carotid artery occlusion.

Physiology & behavior·2026
Same journal

Chronic exposure to artificial light at night dampens rhythms in locomotor activity, metabolism, and sleep in female mice.

Physiology & behavior·2026
See all related articles

Neonatal rat pups emit ultrasonic vocalizations when isolated. This study found that naltrexone, an opioid antagonist, did not affect these isolation-induced vocalizations in Wistar pups, suggesting a complex opioid system involvement.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Animal Behavior

Background:

  • Rat pups exhibit ultrasonic vocalizations (USVs) when separated from their dam and littermates.
  • Morphine administration can reduce these isolation-induced USVs, suggesting opioid system involvement.

Purpose of the Study:

  • To investigate the role of the opioid system in mediating isolation-induced ultrasonic vocalizations in Wistar rat pups.
  • To determine if the opioid antagonist naltrexone affects the rate of USVs in isolated pups.

Main Methods:

  • Wistar rat pups aged 7, 10, 12, 14, and 16 days were tested.
  • Pups received intraperitoneal injections of naltrexone at doses of 0.0, 0.5, 1.0, or 5.0 mg/kg.
  • The rate of isolation-induced ultrasonic vocalizations and other behavioral measures were recorded.

Related Experiment Videos

Main Results:

  • Naltrexone administration did not affect the rate of isolation-induced ultrasonic vocalizations at any tested dose.
  • No significant naltrexone-related changes were observed in other behavioral measures.
  • The findings suggest that the opioid system's role in this vocal behavior may be more complex than initially hypothesized.

Conclusions:

  • The opioid system does not appear to be directly involved in the mediation of isolation-induced ultrasonic vocalizations in developing Wistar rats.
  • Further research is needed to fully elucidate the neurobiological mechanisms underlying these vocalizations.
  • The complexity of the opioid system's involvement in stress and vocal communication warrants further investigation.