Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adolescent development and SLE.

Michael W Beresford1, Joyce E Davidson

  • 1Department of Rheumatology, Royal Liverpool Children's Hospital, Liverpool L1 2 2AP, UK.

Best Practice & Research. Clinical Rheumatology
|March 21, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The association between ethnicity, socioeconomic position and outcomes following initiation of methotrexate in juvenile idiopathic arthritis.

EULAR rheumatology open·2026
Same author

Executive Summary: The 2026 British Society for Rheumatology guideline for the management of children, young people and adults with systemic lupus erythematosus.

Rheumatology (Oxford, England)·2026
Same author

The 2026 British Society for Rheumatology guideline for the management of children, young people and adults with systemic lupus erythematosus.

Rheumatology (Oxford, England)·2026
Same author

The association between ethnicity, socioeconomic position and outcomes following initiation of TNF inhibitors in juvenile idiopathic arthritis: results from the UK JIA Biologics Register.

Rheumatology (Oxford, England)·2026
Same author

Effective Performance of the 2022 American College of Rheumatology/EULAR Classification Criteria for Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Pediatric Patients: An ARChiVe Study.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Validating treat-to-target endpoints in childhood lupus: data-driven sensitivity analyses from the UK JSLE cohort study.

Rheumatology (Oxford, England)·2026

Managing systemic lupus erythematosus (SLE) in adolescents requires careful attention to developmental changes and treatment toxicity. New, less toxic therapeutic options are needed for optimal disease control and adolescent well-being.

Area of Science:

  • Pediatric Rheumatology
  • Adolescent Medicine
  • Immunology

Background:

  • Adolescence involves significant biological and psychosocial development.
  • Systemic lupus erythematosus (SLE) is a complex chronic condition requiring management during this vulnerable period.
  • Current SLE treatments pose toxicity risks for young patients.

Purpose of the Study:

  • To highlight the challenges in managing SLE in adolescents.
  • To emphasize the need for early diagnosis and optimal disease control.
  • To advocate for the development of less toxic treatment regimens for adolescent SLE patients.

Main Methods:

  • This is a review and expert opinion piece, not a clinical trial.
  • Discussion focuses on clinical management strategies and unmet needs.

Related Experiment Videos

  • Literature review on adolescent SLE management and treatment toxicity.

    • Main Results:

    • Optimal SLE management is crucial for normal adolescent development and minimizing long-term sequelae.
    • Existing treatment regimens carry significant toxicity in adolescents.
    • There is a lack of controlled therapeutic studies specifically for adolescents with SLE.

    Conclusions:

    • Effective management of adolescent SLE requires specialist care addressing unique healthcare needs.
    • Developing safer, less toxic treatment protocols is a priority.
    • Further research and controlled trials in adolescent SLE are urgently needed.