Related Experiment Video
Updated: Aug 9, 2026
07:12
Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
Chronic idiopathic pain syndromes
Debajit Sen1, Deborah Christie
1Department of Rheumatology, University College of London Hospitals NHS Trust and Great Ormond Street Hospital NHS Trust, Arthur Stanley House, 40-50 Tottenham Street, London W1T 4NJ, UK. debajit.sen@uclh.nhs.uk
Best Practice & Research. Clinical Rheumatology
|March 21, 2006
Summary
This review provides a practical guide for managing chronic idiopathic pain syndromes, focusing on musculoskeletal conditions in adults and children. It clarifies terminology, reviews epidemiology, and discusses evidence-based medical and non-medical treatments for clinicians.
Area of Science:
- Pain Medicine
- Clinical Practice Guidelines
- Musculoskeletal Disorders
Background:
- Chronic idiopathic pain syndromes represent a complex clinical challenge.
- Distinguishing between adult and pediatric presentations is crucial for effective management.
- Current understanding and nomenclature require clarification for consistent diagnosis and treatment.
Purpose of the Study:
- To present a rational and pragmatic approach to chronic idiopathic pain syndromes.
- To consolidate current knowledge on epidemiology, nomenclature, and clinical findings.
- To review evidence-based medical and non-medical therapeutic interventions.
Main Methods:
- Systematic review of existing literature on chronic idiopathic pain.
- Analysis of epidemiological data and diagnostic criteria.
- Evaluation of therapeutic strategies, including pharmacological and non-pharmacological options.
Main Results:
- Clarification of differing nomenclatures used for these pain syndromes.
- Examination of epidemiological trends in adult and pediatric populations.
- Highlighting key clinical findings and evidence supporting various treatment modalities.
Conclusions:
- A unified, evidence-based approach is needed for managing chronic idiopathic pain.
- Clinicians require practical guidance integrating medical and non-medical interventions.
- This review aims to serve as a daily resource for healthcare professionals treating these conditions.
Related Concept Videos
01:24Chronic Pancreatitis I: Introduction
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:25Chronic Pancreatitis I: Introduction
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
01:25Analgesia and Pain Management
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
01:44Nociception
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
01:17Chronic Bowel Disorders: Introduction
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:21Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...