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Updated: Aug 9, 2026

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis
Published on: November 11, 2014
Shedding B cell identity
Harinder Singh1, Roger Sciammas
1Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, 929 East 57th Street, CIS W522, Chicago, Illinois 60637, USA.
In this issue of Immunity, it is found that the downregulation of Pax-5 during antigen-dependent-terminal differentiation results in a substantial loss of B cell identity and the transition to a plasma cell state.
In this issue of Immunity, it is found that the downregulation of Pax-5 during antigen-dependent-terminal differentiation results in a substantial loss of B cell identity and the transition to a plasma cell state.
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