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Evaluation of ghee based formulation for wound healing activity
Vure Prasad1, Avinash Kumar Dorle
1Department of Pharmaceutical Sciences, Nagpur University, India. vureprasad@gmail.com
Journal of Ethnopharmacology
|March 21, 2006
Summary
A novel formulation combining ghee and neomycin demonstrated significant wound healing properties in rat models. The F-2 formulation, with 50% ghee and 0.5% neomycin, accelerated wound contraction and improved tissue regeneration.
Area of Science:
- Pharmacology
- Wound Healing Research
- Dermatology
Background:
- Traditional remedies like ghee are explored for therapeutic benefits.
- Neomycin is a widely used topical antibiotic for wound infections.
- Evaluating novel formulations for enhanced wound healing is crucial.
Purpose of the Study:
- To assess the wound healing potential of formulations containing neomycin and ghee.
- To compare the efficacy of different ghee concentrations in neomycin formulations.
- To determine the optimal formulation for wound repair.
Main Methods:
- Experimental wound models (excision and incision) were used in rats.
- Formulations with varying ghee (40-50%) and neomycin (0.5%) concentrations were tested.
- Wound contraction, epithelization time, tensile strength, and hydroxyproline content were measured.
Main Results:
- The F-2 formulation (50% ghee, 0.5% neomycin) showed statistically significant wound healing improvements.
- This formulation enhanced wound contraction, reduced closure time, and increased tensile strength.
- Results were comparable to a standard neomycin ointment.
Conclusions:
- The ghee-based formulation (F-2) exhibits potent wound healing capabilities.
- Ghee at 50% concentration in combination with neomycin accelerates tissue regeneration and wound repair.
- This formulation presents a promising alternative for topical wound management.