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Related Experiment Videos

C-reactive protein genotype affects exercise training-induced changes in insulin sensitivity.

Thomas O Obisesan1, Christiaan Leeuwenburgh, Robert E Ferrell

  • 1Department of Kinesiology, University of Maryland, College Park, MD 20742, USA. tobisesan@howard.edu

Metabolism: Clinical and Experimental
|March 21, 2006
PubMed
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Genetic variants in C-reactive protein (CRP) influence how exercise training improves insulin sensitivity and glucose control. Specific CRP gene variants enhance these beneficial training effects in older adults.

Area of Science:

  • Genetics
  • Metabolic Health
  • Exercise Physiology

Background:

  • Chronic inflammation is implicated in insulin resistance development.
  • C-reactive protein (CRP) is a marker of inflammation.
  • Genetic variations in CRP may influence metabolic health and exercise responses.

Purpose of the Study:

  • To investigate if CRP gene variants (-732A/G and +219G/A) affect insulin and glucose measures.
  • To determine if these CRP variants impact training-related changes in insulin sensitivity and glucose metabolism.
  • To explore the association between CRP gene variants and exercise-induced improvements in metabolic parameters.

Main Methods:

  • Cross-sectional study with 61 participants (50-75 years old).
  • Baseline assessments included glucose tolerance, maximal oxygen consumption, body composition, CRP levels, and genotyping.

Related Experiment Videos

  • Participants underwent 24 weeks of aerobic exercise training with repeated testing.

    • Main Results:

    • CRP -732A/G G allele carriers showed lower baseline postprandial glucose and reduced post-training CRP levels.
    • G allele carriers experienced significantly greater improvements in insulin sensitivity index (ISI) and insulin area under the curve (AUC) after training compared to A allele homozygotes.
    • The CRP -732A/G variant and a combined haplotype (-732A/G and +219G/A) significantly modulated training-induced enhancements in ISI and insulin AUC.

    Conclusions:

    • The CRP -732A/G gene variant plays a role in modulating exercise training-related improvements in insulin sensitivity and glucose metabolism.
    • A specific haplotype of CRP gene variants (-732A/G and +219G/A) significantly influences training-induced changes in insulin sensitivity and insulin AUC.
    • These findings suggest a genetic predisposition influencing the effectiveness of exercise interventions for metabolic health.