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Chemoselective hydrazone formation between HYNIC-functionalized peptides and (18)F-fluorinated aldehydes

Kjerstin Bruus-Jensen1, Thorsten Poethko, Margret Schottelius

  • 1Department of Nuclear Medicine, Klinikum rechts der Isar, Technischen Universität München, D-81675 Munich, Germany.

Nuclear Medicine and Biology
|March 21, 2006
PubMed
Summary

A new two-step radiolabeling strategy uses hydrazone formation for (18)F-fluorinated peptides, enabling quantitative PET imaging. This method is fast, versatile, and achieves high yields under mild conditions.

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