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[Effect of S-bioallethrin on human lymphocyte]
Yue Liu1, Li-Yan Liang, Wen-Li Ma
1Institute of Genetic Engineering, Southern Medical University, Guangzhou 510515, China. sunshine@fimmu.com
Objective:
To study the effect of the S-bioallethrin on human lymphocytes by microarray technique.
Methods:
The changes of normal human lymphocytes treated with S-bioallethrin were examined with light microscope, flow cytometry, electron microscope, DNA ladder and microarray techniques.
Results:
Morphological study showed that the lymphocytes underwent apoptosis after S-bioallethrin exposure, which as further confirmed by the expression changes of 346 genes.
Conclusion:
S-bioallethrin can induce apoptosis of normal human lymphocytes and changes in their gene expression profiles.
