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Updated: Aug 9, 2026

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution
Published on: April 16, 2019
[Nonalcoholic steatohepatitis: a clinicopathological analysis of liver biopsy in 32 cases]
Jia-rong Meng1, Rui-dan Zheng, Ming-feng Zhang
1Department of Pathology, 175 Hospital of PLA, Zhangzhou 363000, China. Mengjiarong@sina.com
Objective:
To investigate the clinicopathological features of nonalcoholic steatohepatitis (NASH) and elucidate its diagnosis and differential diagnosis.
Methods:
Liver biopsy tissues and clinical data of 32 patients with NASH were collected and the clinicopathological findings by HE and Masson staining were evaluated for NASH grading.
Results:
Ballooning degeneration of the liver cells and fibrosis around hepatic sinusoid was scarce in mild NASH cases and increased in moderate to severe cases. Steatotic and inflammatory cells in the liver lobes decrease in liver cirrhosis related to seatohepatitis.
Conclusion:
Ballooning degeneration of the liver cells and fibrosis around the hepatic sinusoid have important value in differential diagnosis of mild from moderate to severe NASH, and correct histological grading benefits clinical intervention and prognostic evaluation of NASH.
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