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Related Experiment Videos

Hypercholesterolemia does not alter endothelial function in spontaneously hypertensive rats.

B Lorkowska1, M Bartus, M Franczyk

  • 1Department of Experimental Pharmacology, Chair of Pharmacology, Jagiellonian University, ul Grzegorzecka 16, 31-531 Krakow, Poland.

The Journal of Pharmacology and Experimental Therapeutics
|March 21, 2006
PubMed
Summary

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High cholesterol did not impair endothelial function in hypertensive rats. This study found that hypercholesterolemia does not affect nitric oxide (NO)-dependent or prostacyclin (PGI2)-dependent endothelial function in spontaneously hypertensive rats (SHR).

Area of Science:

  • Cardiovascular Science
  • Endocrinology
  • Vascular Biology

Background:

  • Endothelial dysfunction is linked to hypercholesterolemia and hypertension in humans.
  • The impact of hypercholesterolemia on endothelial function in the context of pre-existing hypertension requires further investigation.

Purpose of the Study:

  • To determine if hypercholesterolemia exacerbates endothelial dysfunction in spontaneously hypertensive rats (SHR) with established hypertension.
  • To evaluate the effects of a high-cholesterol diet on nitric oxide (NO) and prostacyclin (PGI2) production in the aorta of SHR and normotensive WKY rats.

Main Methods:

  • Spontaneously hypertensive rats (SHR) and WKY rats were fed a high-cholesterol diet for 12 weeks.
  • Endothelial function was assessed in isolated thoracic aortic rings by measuring NO-dependent relaxation and vasoconstriction.

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  • Plasma levels of monocyte chemoattractant protein 1 (MCP-1) were analyzed.

    • Main Results:

    • The high-cholesterol diet significantly increased total cholesterol and LDL levels in both SHR and WKY rats.
    • Despite hypercholesterolemia, basal nitric oxide (NO) production and NO-dependent relaxation remained unaffected in the aortas of both rat groups.
    • Prostacyclin (PGI2) production was not altered by the hypercholesterolemic diet, and plasma MCP-1 levels showed only a slight increase.

    Conclusions:

    • Hypercholesterolemia does not induce endothelial dysfunction in rats with pre-existing hypertension.
    • The study suggests that hypercholesterolemia alone, even with hypertension, may not be sufficient to trigger significant endothelial dysfunction or a strong inflammatory response, which are precursors to atherosclerosis.