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Microbial considerations in genetically engineered mouse research.

Craig L Franklin1

  • 1Research Animal Diagnostic Laboratory and Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA.

ILAR Journal
|March 21, 2006
PubMed
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Microbial infections in genetically engineered mice (GEM) can alter their phenotype, potentially invalidating research findings. Careful management is crucial to prevent economic losses and ensure accurate scientific conclusions.

Area of Science:

  • * Laboratory animal science
  • * Genetically engineered rodent models
  • * Infectious disease research

Background:

  • * Microbial infections in laboratory rodents can compromise research validity.
  • * Genetically engineered mice (GEM) exhibit increased susceptibility to infections.
  • * Infections can alter GEM phenotypes, confounding studies of gene function.

Purpose of the Study:

  • * To review the impact of microbial infections on GEM phenotypes.
  • * To explore host-microbe interactions and their role in disease modeling.
  • * To discuss challenges in preventing and controlling infections in GEM.

Main Methods:

  • * Literature review focusing on naturally occurring infections in GEM.
  • * Analysis of host-pathogen interactions and their influence on phenotype.

Related Experiment Videos

  • * Examination of immunomodulation effects in genetically altered hosts.

    • Main Results:

    • * Microbial infections can significantly alter GEM phenotypes, impacting research outcomes.
    • * Host immune responses, modified by genetic engineering, influence susceptibility.
    • * Novel host:microbe interactions have led to new disease models and pathogen discoveries.
    • * Economic implications of infections in expensive GEM are substantial.

    Conclusions:

    • * Microbial infections pose a significant threat to the integrity of research using GEM.
    • * Understanding host-microbe interactions is key to accurate interpretation of GEM studies.
    • * Effective strategies for infection prevention and control are essential for GEM research.