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Related Experiment Videos

Multimodality stroke prevention.

Nerses Sanossian1, Bruce Ovbiagele

  • 1Stroke Center and Department of Neurology, UCLA Medical Center, Los Angeles, California 90095, USA.

The Neurologist
|March 21, 2006
PubMed
Summary

Implementing multimodality vascular prevention for stroke patients is crucial. A systematic, evidence-based approach across care settings improves treatment rates and clinical outcomes for atherothrombotic disease.

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Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Preventive Medicine

Background:

  • Stroke prevention offers significant potential for reducing societal burden.
  • Multifactorial pathogenesis of vascular disease necessitates novel combination therapies.
  • A paradigm shift towards multimodality vascular prevention is emerging.

Purpose of the Study:

  • To review evidence for multimodality vascular prevention in ischemic stroke patients with atherosclerosis.
  • To discuss conventional and novel vascular risk factors and prediction models.
  • To explore implementation strategies and bridge the knowledge-treatment gap.

Main Methods:

  • Comprehensive review of evidence for preventive therapies.
  • Elaboration on risk factors, prediction models, and treatment options.
  • Discussion of national guidelines, controversies, and future research.

Main Results:

  • Broadening therapeutic options for recurrent vascular event prevention are presented.
  • Conventional and novel risk factors, therapies (antithrombotics, statins, etc.), and lifestyle modifications are detailed.
  • A hospital-based intervention to improve in-hospital initiation of preventive therapies is described.

Conclusions:

  • A timely, systematic, evidence-based multimodal approach is essential for atherothrombotic disease in stroke patients.
  • This approach should transcend the continuum of care.
  • Improved treatment rates and clinical outcomes are expected with effective implementation.

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