How to evolve a silk purse from a sow's ear

pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism.

Organic & biomolecular chemistry·2018

Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.

Journal of the American Chemical Society·2018

Stereospecific Formation of Z-Trisubstituted Double Bonds by the Successive Action of Ketoreductase and Dehydratase Domains from trans-AT Polyketide Synthases.

Biochemistry·2018

Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes.

Biochemistry·2017

Stereospecific Formation of E- and Z-Disubstituted Double Bonds by Dehydratase Domains from Modules 1 and 2 of the Fostriecin Polyketide Synthase.

Journal of the American Chemical Society·2017

Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay.

Journal of the American Chemical Society·2017

Early maturation of host antimicrobial peptide defences is associated with host-pathogen coexistence.

Nature chemical biology·2026

Proteoform-specific enrichment of phosphopeptide isomers by polymer-based synthetic receptors.

Nature chemical biology·2026

Protein stability is determined by single-site bias rather than pairwise covariance.

Nature chemical biology·2026

Tumor immune cell targeting chimeras reprogram tumor-associated macrophages.

Nature chemical biology·2026

Structural and biochemical basis for cannabinoid cyclase activity in marine bacterial flavoenzymes.

Nature chemical biology·2026

Cephalotaxinone enzymes reveal a whole plant model for homoharringtonine biosynthesis.

Nature chemical biology·2026

Three-dimensional Magnetic Resonance Imaging Segmentation for Preoperative Planning in Gluteal Polymer Complications.

Plastic and reconstructive surgery. Global open·2026

Undersized lung grafts in chronic obstructive pulmonary disease transplant recipients: risk factor or acceptable compromise?

Transplant international : official journal of the European Society for Organ Transplantation·2026

Effect of incorporating long polyethylene fibers in resin composite on polymerization shrinkage strain and degree of monomer conversion (An In-vitro Study).

BMC oral health·2026

Unlocking the potential of chemically modified Bauhinia purpurea L fiber for enhanced composite reinforcement application.

International journal of biological macromolecules·2026

Sulfonated polyvinyl chloride microparticles onto stainless-steel sheets: A cationic-exchanger planar phase for extraction of basic drugs in saliva samples.

Journal of chromatography. A·2026

Preparation and study of non-thrombotic and biostable sulfobetaine-modified small-diameter polyurethane vascular grafts.

Colloids and surfaces. B, Biointerfaces·2026

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How to evolve a silk purse from a sow's ear

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pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism.

Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.

Stereospecific Formation of Z-Trisubstituted Double Bonds by the Successive Action of Ketoreductase and Dehydratase Domains from trans-AT Polyketide Synthases.

Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes.

Stereospecific Formation of E- and Z-Disubstituted Double Bonds by Dehydratase Domains from Modules 1 and 2 of the Fostriecin Polyketide Synthase.

Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay.

Early maturation of host antimicrobial peptide defences is associated with host-pathogen coexistence.

Proteoform-specific enrichment of phosphopeptide isomers by polymer-based synthetic receptors.

Protein stability is determined by single-site bias rather than pairwise covariance.

Tumor immune cell targeting chimeras reprogram tumor-associated macrophages.

Structural and biochemical basis for cannabinoid cyclase activity in marine bacterial flavoenzymes.

Cephalotaxinone enzymes reveal a whole plant model for homoharringtonine biosynthesis.

Three-dimensional Magnetic Resonance Imaging Segmentation for Preoperative Planning in Gluteal Polymer Complications.

Undersized lung grafts in chronic obstructive pulmonary disease transplant recipients: risk factor or acceptable compromise?

Effect of incorporating long polyethylene fibers in resin composite on polymerization shrinkage strain and degree of monomer conversion (An In-vitro Study).

Unlocking the potential of chemically modified Bauhinia purpurea L fiber for enhanced composite reinforcement application.

Sulfonated polyvinyl chloride microparticles onto stainless-steel sheets: A cationic-exchanger planar phase for extraction of basic drugs in saliva samples.

Preparation and study of non-thrombotic and biostable sulfobetaine-modified small-diameter polyurethane vascular grafts.

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How to evolve a silk purse from a sow's ear

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