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What process is glycolytic stoichiometry optimal for?

Alicia Esteban del Valle1, J Carlos Aledo

  • 1Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, 29071, Málaga, Spain.

Journal of Molecular Evolution
|March 21, 2006
PubMed
Summary

Glycolysis optimizes for power output, not ATP production rate. Different stoichiometries yield maximal power, but the current 2 ATP per glucose likely evolved for efficient ATP hydrolysis energy.

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Area of Science:

  • Biochemistry
  • Cellular Metabolism
  • Bioenergetics

Background:

  • The traditional view posits glycolysis optimizes ATP production rate.
  • The glycolytic stoichiometry of 2 ATP per glucose is widely accepted.

Purpose of the Study:

  • To investigate the optimization principles governing glycolysis.
  • To determine if glycolysis maximizes ATP production rate or output power.
  • To analyze the impact of stoichiometric variations on cellular processes.

Main Methods:

  • Application of a nonequilibrium thermodynamic approach.
  • Theoretical analysis of glycolytic stoichiometry and its consequences.

Main Results:

  • Glycolysis operates at optimal output power, not maximal ATP production flow.

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  • Maximal output power is achievable with variable glycolytic stoichiometries.
  • Altering stoichiometry significantly impacts the efficiency of ATP-dependent cellular functions.

    • Conclusions:

    • The observed glycolytic stoichiometry may be an evolutionary adaptation.
    • This adaptation likely optimizes the energy released during ATP hydrolysis for cellular functions.