Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Encapsulated hepatocellular carcinoma: CT-pathologic correlations.

Jae Hoon Lim1, Dongil Choi, Cheol Keun Park

  • 1Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, 135-710, Seoul, South Korea. jhlim@smc.samsung.co.kr

European Radiology
|March 21, 2006
PubMed
Summary

The integrity of the hepatocellular carcinoma (HCC) capsule on CT scans accurately predicts its presence and invasion on pathology. This finding aids in assessing tumor spread and prognosis for HCC patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated Installation System for Joint Casing with Circumferential Temperature Control in District Heating Pipelines Using a Heat-Shrinkable PEX Tube.

Polymers·2026
Same author

Ovarian Metastasis from Human Papillomavirus-associated Usual-type Endocervical Adenocarcinoma: Clinicopathological Characteristics for Distinguishing from Primary Ovarian Mucinous or Endometrioid Tumor.

In vivo (Athens, Greece)·2024
Same author

Clinicopathologic Significance of Quaking Expression in Hepatocellular Carcinoma.

In vivo (Athens, Greece)·2024
Same author

Loss of F-Box and Leucine Rich Repeat Protein 5 (FBXL5) Expression Is Associated With Poor Survival in Patients With Hepatocellular Carcinoma After Curative Resection: A Two-institute Study.

Cancer genomics & proteomics·2023
Same author

Prognostic Significance of ARID1A Expression Patterns Varies with Molecular Subtype in Advanced Gastric Cancer.

Gut and liver·2023
Same author

Synthetic Study of Dragmacidin E: Enantioselective Construction of the Seven-Membered Ring-Fused Indole Skeleton with Contiguous Stereocenters.

The Journal of organic chemistry·2023

Area of Science:

  • Hepatobiliary Medicine
  • Diagnostic Imaging
  • Surgical Pathology

Background:

  • Hepatocellular carcinoma (HCC) is a common primary liver cancer.
  • Accurate staging and assessment of tumor invasion are critical for patient management.
  • The role of the tumor capsule in HCC progression and its detection by imaging requires further clarification.

Purpose of the Study:

  • To evaluate the correlation between the presence and integrity of the hepatocellular carcinoma (HCC) capsule visualized on dynamic CT scans and histopathological findings.
  • To determine if CT-based capsule assessment can predict tumor invasion and microvascular emboli.

Main Methods:

  • Retrospective analysis of dynamic CT scans from 73 patients with 75 nodular HCCs.
  • Evaluation of capsule visualization and integrity on CT.

Related Experiment Videos

  • Correlation of CT findings with histopathological examination of resected HCC specimens, including capsule invasion and microvascular emboli.

    • Main Results:

    • Capsule visualization on CT correlated significantly with its presence on histopathology (P<0.001).
    • Capsule disruption on CT was associated with tumor invasion (P=0.003) and microvascular emboli (P<0.001) on histopathology.
    • Intact HCC capsules on CT indicated absence of microvascular tumor emboli.

    Conclusions:

    • Dynamic CT is a reliable method for assessing the presence and integrity of HCC capsules.
    • CT-detected capsule integrity is a strong indicator of tumor encapsulation and absence of microvascular invasion.
    • These findings can improve non-invasive staging and risk stratification for HCC.