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[Progress of Chinese medicinal study on collateral circulation of coronary artery]

Xiang-wei Zhang1, Bang-han Ding, Min-zhou Zhang

  • 1The Cardiac Medical Department, Guangdong Provinal Hospital of Traditional Chinese Medicine, Guangzhou 510120. xixi96@hotmail.com

Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine
|March 22, 2006
PubMed

Insights

Chinese medicine enhances coronary artery collateral circulation by regulating key growth factors. This review highlights the role of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) in these effects.

Area of Science:

  • Cardiovascular Research
  • Integrative Medicine
  • Pharmacology

Context:

  • Coronary artery disease (CAD) remains a leading cause of mortality worldwide.
  • Collateral circulation plays a crucial role in myocardial protection during ischemic events.
  • Limited therapeutic options exist for enhancing endogenous collateral vessel formation.

Purpose:

  • To review the scientific literature on the effects of traditional Chinese medicine (TCM) on coronary collateral circulation.
  • To elucidate the molecular mechanisms underlying TCM's influence, focusing on vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF).
  • To assess the potential of TCM as an adjunctive therapy for improving coronary collateralization.

Summary:

  • Traditional Chinese medicine formulations have demonstrated a regulatory effect on coronary artery collateral circulation.
  • Key findings indicate that TCM can modulate the expression and activity of VEGF and FGF, crucial mediators of angiogenesis.
  • Evidence suggests TCM interventions promote the development and function of collateral vessels in the coronary system.

Impact:

  • This review provides a comprehensive overview of TCM's role in cardiovascular health, specifically in enhancing collateral circulation.
  • Identifies specific TCM components and pathways that could be targeted for novel therapeutic strategies.
  • Highlights the potential of integrating TCM with conventional treatments for improved outcomes in patients with coronary artery disease.

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