Related Experiment Video
Updated: Aug 9, 2026

Single Cell Measurement of Dopamine Release with Simultaneous Voltage-clamp and Amperometry
Published on: November 21, 2012
Effects of amphetamine on schedule-induced polydipsia
Yia-Ping Liu1, Hung-Chin Wang, Ching-Jiunn Tseng
1Department of Drug Addiction, Armed Forces Beitou Hospital, Taiwan, ROC.
Amphetamine (AMPH) affects schedule-induced polydipsia (SIP) and behavioral activation differently over time. Initial AMPH doses reduced licking but increased nose pokes, with effects diminishing in later stages.
Area of Science:
- Neuroscience
- Behavioral Pharmacology
Background:
- Schedule-induced polydipsia (SIP) is a model for studying behavioral patterns.
- Behavioral activation is a key concept in understanding motivation and reward.
Purpose of the Study:
- To investigate the dose-dependent effects of amphetamine (AMPH) on schedule-induced polydipsia (SIP).
- To explore the association between AMPH administration and behavioral activation.
- To examine the temporal effects of AMPH on SIP and related behaviors.
Main Methods:
- Experiments involved administering various doses of amphetamine (AMPH) over different durations.
- Two distinct treatment stages with a two-month interval were employed.
- Behavioral activation and SIP performance metrics, including licking and nose poking, were recorded.
Main Results:
- AMPH induced behavioral depression, with reduced potency in the second treatment stage.
- In the first stage, AMPH decreased licking frequency and increased nose poking frequency.
- In the second stage, AMPH did not affect licking frequency but reduced licking efficiency and nose poking frequency.
Conclusions:
- SIP behavior is linked to central dopaminergic system function.
- AMPH's effects on SIP are modulated by treatment duration and timing.
- Behavioral competition and stress coping strategies may influence AMPH's impact on SIP.
More Related Videos
09:16A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
08:10A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits
Published on: November 24, 2015
Related Concept Videos
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
Adrenergic Agonists: Indirect-Acting Agents
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral bioavailability, and...
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...
Drug Abuse and Addiction: Pharmacological Phenomena
Adrenergic Agonists: Mixed-Action Agents
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
Desensitization and Tachyphylaxis
Several...