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Updated: Jun 29, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
Dynamical structure of peptide molecules
Yoshiyuki Kawashima1, Tsuyoshi Usami, Nobukimi Ohashi
1Department of Applied Chemistry, Kanagawa Institute of Technology, Atsugi, Kanagawa 243-0292, Japan.
Abstract:
In view of the importance of the peptide linkage in structural biology, we have carried out intensive investigations on peptide molecules consisting of a peptide linkage with one or two substituents in the gas phase by Fourier transform microwave spectroscopy, paying special attention to the internal rotation of the substituents relative to the central linkage framework. We have found that, in sharp contrast with the stiff structure around the central C-N bond of the linkage, the internal rotations of the substituents are of low frequency and thus of large amplitude and are extremely susceptible to their local environment such as the presence of other substituents.
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