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Identification of a diuretic hormone of Locusta migratoria
E Lehmberg1, R B Ota, K Furuya
1Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel.
Biochemical and Biophysical Research Communications
|September 16, 1991
Abstract:
We have isolated a peptide from brains and corpora cardiaca of Locusta migratoria which is immunologically related to the diuretic hormone of Manduca sexta. We determined its structure as a 46 amino acid linear peptide with 43-50% identity to the M. sexta hormone. Moreover, we showed that the new peptide functions as a diuretic hormone in L. migratoria, stimulating urine production by Malpighian tubules and elevating levels of cAMP in tubules.