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Related Experiment Videos

Split liver transplantation.

H Yersiz1, A M Cameron, I Carmody

  • 1Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095-7054, USA. hyersiz@mednet.ucla.edu

Transplantation Proceedings
|March 22, 2006
PubMed
Summary
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Split liver transplantation (SLT) expands organ availability by dividing deceased donor livers for two recipients. This technique, particularly in situ splitting, is increasingly vital for adult and pediatric liver transplants.

Area of Science:

  • Hepatobiliary surgery
  • Transplant surgery
  • Organ donation

Background:

  • Organ failure affects 75,000 Americans annually, with 15% of transplant candidates dying while waiting.
  • Expanding the organ donor pool is critical to address transplant waiting lists.
  • Advances in understanding liver anatomy have enabled innovative organ utilization strategies.

Purpose of the Study:

  • To review the evolution and application of split liver transplantation (SLT) techniques.
  • To highlight the benefits and challenges of in situ liver splitting.
  • To assess the impact of SLT on transplant volumes.

Main Methods:

  • Review of historical liver transplantation techniques, including reduced-size liver transplantation (RLT).
  • Description of split liver transplantation (SLT) modifications for deceased and living donors.

Related Experiment Videos

  • Analysis of in situ splitting technique, emphasizing its advantages and complexities.

    • Main Results:

    • Split liver transplantation (SLT) evolved from early reduced-size techniques to enable utilization of both liver segments.
    • In situ splitting, performed in the donor, reduces cold ischemia time and simplifies surgical procedures.
    • At UCLA, over 120 in situ splits have been performed, becoming the standard approach for optimal donors.

    Conclusions:

    • Split liver transplantation (SLT) significantly increases the number of available liver grafts.
    • In situ splitting offers technical advantages but requires specialized expertise and coordination.
    • SLT represents 10% of adult and 40% of pediatric liver transplants at UCLA, demonstrating its crucial role.