Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Barriers to optimizing vitamin D3 intake for the elderly.

Robert P Heaney1

  • 1Creighton University, Omaha, NE 68178, USA. rheaney@creighton.edu

The Journal of Nutrition
|March 22, 2006
PubMed
Summary

Older adults require more vitamin D3 due to decreased skin synthesis. Current upper intake levels may hinder public health efforts to maintain optimal vitamin D status in the elderly.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Serum 25-Hydroxyvitamin D Concentrations ≥40 ng/ml Are Associated with >65% Lower Cancer Risk: Pooled Analysis of Randomized Trial and Prospective Cohort Study.

PloS one·2018
Same author

Serum 25-Hydroxyvitamin D Concentrations ≥40 ng/ml Are Associated with >65% Lower Cancer Risk: Pooled Analysis of Randomized Trial and Prospective Cohort Study.

PloS one·2016
Same author

Is Vitamin D Inadequacy in Early Life an Instance of the "Barker Hypothesis"?

Nutrition today·2016
Same author

Quantifying the vitamin D economy.

Nutrition reviews·2015
Same author

Screening for vitamin D deficiency: is the goal disease prevention or full nutrient repletion?

Annals of internal medicine·2015
Same author

Making Sense of the Science of Sodium.

Nutrition today·2015

Area of Science:

  • Nutritional Science
  • Gerontology
  • Biochemistry

Background:

  • Vitamin D3 is crucial for metabolic utilization, with current daily requirements estimated at 4000 IU (100 µg), double the tolerable upper intake level (UL).
  • While young individuals synthesize most vitamin D3 cutaneously, this capacity diminishes with age.
  • Reduced skin synthesis necessitates increased oral vitamin D3 intake to maintain adequate serum 25-hydroxyvitamin D [25(OH)D] levels.

Purpose of the Study:

  • To determine the additional oral vitamin D3 intake required to achieve optimal serum 25(OH)D concentrations in older populations.
  • To identify barriers to public health strategies aimed at improving vitamin D status in the elderly.

Main Methods:

  • Analysis of population distribution of serum 25(OH)D values.
  • Utilizing available dose-response data for vitamin D3.
  • Estimating required oral vitamin D3 input to reach target serum 25(OH)D levels in older women.

Main Results:

  • An additional 2600 IU/d (65 µg/d) of oral vitamin D3 is needed for 97.5% of older women to reach desirable serum 25(OH)D levels.
  • Age-related decline in vitamin D3 synthesis is a significant factor.
  • The current tolerable upper intake level (UL) for vitamin D3 presents a challenge.

Conclusions:

  • Optimizing vitamin D status in the elderly is hindered by the combination of reduced cutaneous synthesis and the established UL.
  • Public health strategies must consider higher oral intake recommendations for older adults.
  • Further research into safe and effective vitamin D supplementation strategies for the aging population is warranted.

Related Experiment Videos