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Updated: Aug 9, 2026
Isolation, Transfection, and Culture of Primary Human Monocytes
Published on: December 16, 2019
Effects of human interleukin 7 on HIV-1 replication in monocyte-derived human macrophages
Haihan Song1, Emi E Nakayama, Tatsuo Shioda
1Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Abstract:
Interleukin 7 (IL-7) contributes to development and proliferation of T cells. We investigated the effect of IL-7 on HIV-1 infected monocyte-derived human macrophages. IL-7 treatment of macrophages at a concentration of 10 ng/ml reduced replication of the R5 HIV-1 strain by approximately 50%. Meanwhile, HIV-1-infected macrophages themselves could excrete approximately 20% more IL-7 than uninfected macrophages. These results suggest that IL-7 could be used as a therapeutic modality to recover CD4 T cells.
