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Related Experiment Videos

[Isoniazid-induced visual hallucinosis].

Sonia Maâlej1, Ikram Drira, Ramzi Ben Mefteh

  • 1Hôpital Abderrahmen Mami Ariana, Tunis, Tunisie. s.maalej@gnet.tn

Presse Medicale (Paris, France : 1983)
|March 22, 2006
PubMed
Summary

Isoniazid, an antituberculosis drug, can rarely cause psychiatric issues like visual hallucinosis. This case highlights potential links to isoniazid treatment, suggesting mechanisms like vitamin B6 deficiency.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Infectious Diseases

Background:

  • Isoniazid is a primary antituberculosis medication.
  • Psychiatric manifestations are rare side effects of isoniazid therapy.
  • Hallucinosis is an uncommon presentation of isoniazid-induced psychiatric effects.

Observation:

  • A 42-year-old woman with lymph node tuberculosis developed visual hallucinosis and headache.
  • Symptoms emerged three weeks after initiating a four-drug antituberculosis regimen including isoniazid.
  • Cessation of isoniazid led to symptom resolution, with anxiolytic treatment aiding recovery.

Findings:

  • The clinical presentation strongly suggests isoniazid as the causative agent for visual hallucinosis.
  • Potential mechanisms include isoniazid-induced vitamin B6 deficiency.

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  • Interference with bioamine metabolism by isoniazid is another proposed mechanism.

    • Implications:

    • Clinicians should consider isoniazid toxicity in patients presenting with psychiatric symptoms during tuberculosis treatment.
    • Monitoring for and managing potential vitamin B6 deficiency may be crucial.
    • Further research into the neurobiological effects of isoniazid is warranted.