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Stereospecific backbone methylation of pyrrolidine-amide oligonucleotide mimics (POM)

Anila I Khan1, T H Samuel Tan, Jason Micklefield

  • 1School of Chemistry, University of Manchester, Faraday Building, Sackville Street, PO Box 88, Manchester, UKM60 1QD.

Chemical Communications (Cambridge, England)
|March 22, 2006
PubMed

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Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...