Related Experiment Video
Updated: Aug 9, 2026

Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease
Published on: October 20, 2023
Blood-brain barrier dysfunction and recovery
1Blood-Brain Barrier Research Group, Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, University of Leiden, Gorlaeus Laboratories, Leiden, The Netherlands. B.Boer@LACDR.LeidenUniv.NL
Abstract:
In this paper we discuss the importance of the blood-brain barrier (BBB) as an interface between blood and brain. Many (brain) diseases change the functionality and integrity of the BBB. Mostly this results in increased BBB permeability. Therefore we have studied de various signal transduction routes that are influenced by inflammatory stimuli. The radical scavenger N-acetylcysteine was able to protect the BBB against inflammatory stimuli. Similar results were found following application of glucocorticoids. In addition, it was observed that glucocorticoids and interferon-alpha,beta increased the tightness of the in vitro BBB and when given together a potentiating effect was seen.
More Related Videos
07:13A Simple and Reproducible Method to Prepare Membrane Samples from Freshly Isolated Rat Brain Microvessels
Published on: May 7, 2018
07:22Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative Disease
Published on: November 8, 2017
Related Concept Videos
The Blood-brain Barrier
Physiological Barriers
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
Neurogenesis and Regeneration of Nervous Tissue
Cerebral Edema ll: Pathophysiology
Transcellular Transport of Solutes
Secondary Spinal Cord Injury llI: Pathophysiology